Please select a reason for escalating this post to the WTE moderators: Connect with our community members by starting a discussion. I had also changed from an estradiol tablet to estradiol patches in my first FET. Does this harm the embryo or reduce its potential for success? 2 - IVF both miscarriages around 6 weeks I didnt realize you could transfer your embryos to another clinic. Aneuploids on the other hand, at least based on 1 study, seem to have a 100% miscarriage rate. Or is it worth having the actual tests done? Any experiences with Day 6 blastocyst - Fertility Network UK All 3 embryos made it to day 5 blastocyst on the 6th day we did pgs testing. Terms are highlighted every 3rd time to avoid repetition. So the advantage with PGT-A may be in determining which embryos are completely unfit for transfer, at least based on this study. I know that every cycle + embryo is different, but it's so hard to not compare cycles. I know PGS tested embryos can still have issues but its been 4 transfers now with no success so Im wondering if theres a deeper issue. So all the aneuploid embryos that were transferred either didnt implant, or miscarried. For now its probably best to avoid having to thaw and biopsy if possible. So the next step is transfer and my clinic is telling me to go for era in order to increase my chances. Thanks! He also answers questions in his private Facebook group. I actually didnt have embryos to bring with me when we switched. To count these women in, we can look at the per retrievaldata: Now when we look at everyone the stats look much different! Why do euploid embryos miscarry? A case-control study - PubMed Best of luck! However, another doctor (2nd opinion) claimed that Receptiva would only be conducted for implantation failure and for those who had never seen positive pregnancy tests. Then a frozen cycle BFN. I have expressed my concern but my RE believes it is more about the pattern. If it were me and it was my last embryo I would definitely ask about (possibly even push for) immune protocol and the ERA just to cover all my bases. (2018)found a slight reduction inlive birth ratecompared to single biopsied embryos (50% vs 58%), but this was notstatistically significant. Low hCG levels. Does PGT-A reduce the chances of miscarriage? If I had transferred two without PGS, there would have been a significant chance that both would have been abnormal. When an embryo doesn't implant or begins implantation but stops developing soon after (biochemical pregnancy), the most common cause is a chromosomal abnormality in the embryo itself (meaning it has too much or too little genetic material). It provides a greater scope of information to geneticists, it reveals mosaicism within the embryos, as well as minimising the risk of receiving false positive or negative results. I'm doing the full "recurrent pregnancy loss" blood workup and karyotype genetic testing on my husband and me before we try again. In contrast to mosaic embryos that are a mix of euploid and aneuploid cells, aneuploid embryos are completely aneuploid and all the cells are abnormal. My first fresh transfer ended in miscarriage due to low progesterone, I was on supplements but not enough. Hoping to hear from them soon . Praying you did and thank you for the advice! My clinic does allow each patient to continue with one retrieval with only 1-2 follicles, however, for cost reasons since we're doing ICSI and PGS testing I'm considering cancelling the cycle. I feel so lucky that I found this community. The Munne et al. Chemical pregnancies occur so early that many people who miscarry don't realize it. The educational health content on What To Expect is reviewed by our medical review board and team of experts to be up-to-date and in line with the latest evidence-based medical information and accepted health guidelines, including the medically reviewed What to Expect books by Heidi Murkoff. The antibiotics were pretty strong, but I think they upset my stomach more than they did my husband. After each failed transfer, my RE did a lot of additional testing including a Yale EFT biopsy for receptivity and a clotting test to see if I needed lovenox and/or baby aspirin. There was also no difference with Day 7, although the sample size was very small. Dogpark in reply to Mogwai_2 3 years ago. The psychologist who ran the group, who also happened to be an RE at my fertility clinic, explained that sometimes you have a seemingly perfect embryo, perfect uterine lining, and the FET just fails. My RE felt that having one good embryo was not a guarantee, so 4 rounds of retrievals it took before we had a few to work with. I have one more embryo remaining. Hello. I did not do an ERA although I know a lot of people who have and have gathered helpful info from it. Success stories with 2 PGS normal embryos? - HealthUnlocked Wondering if anyones had a similar experience or has any advice. We have not done a hysteroscopy but will ask my dr if we can do one to check and at least rule that out. I have a similar story. It is seriously invaluable to me. I wanted to point out thestandard deviationof this data is large, roughly 30% for each group. wow, Im so glad you were able to get a second opinion. So sorry this happened and good luck to you. I am so frustrated and emotional, I am not having any pregnancy symptoms, beside some minor vaginal cramping and sore breast. (2014)found no difference inongoing pregnancybetween grades (about 50% for each category). For that reason my RE said she would start testing such as ERA after a second failed transfer but didnt think it was necessary after the first failed transfer. A recent 2019 study looked at 130,000 biopsies by NGS tested (this is the current testing method): Demko et al. Though it's one of the most successful forms of assisted reproductive technology, the live birth rate from one IVF cycle is about 55.6% for people under 35, and 40.8% for folks between the ages of. That is, you definitely need an embryo with normal chromosome, but it's not the only variable to consider. My doctor thought it was possibly due to retained products of conception. Then my 3rd transfer and 2nd FET is now my baby boy growing well at 16 weeks 4 days. Im still u sure if this will go to term, but getting a 2nd opinion from a specialist in RPL sure has made a difference. Aluko et al. What is the percentage of PGT normal embryos after 40 - Reddit Theper retrievalstatistic helps to see the chancesbefore PGStesting. It had an extra chromosome from the sperm and another from the egg. Have you been tested for APS (antiphosolipid syndrome)? The views expressed in community are solely the opinions of participants, and do not reflect those of What to Expect. So I tried to find information through the site because I know topics like this have been posted before, BUT when I pull the results somehow PGS results in a whole lot of pregnancy posts as pg is used as a shortcut, and I am so all set with that. I had biopsies after a polyp removal which showed residual B cells (even after 3 rounds of antibiotics), my RE didn't think much of it. I would Love and Need your opinions on this. My RE had said shes usually very cautious when it comes to sending embryos out for PGS testing only because the process can sometimes compromise the embryo itself. Your post will be hidden and deleted by moderators. Im very sorry and hope you can find the strength to continue. I feel like your doctor should have mentioned the ERA and biopsy by now. Im sorry to hear of your loss! I just looked briefly online and saw mixed reviews about embryos being damaged when shipped. Good luck to you on this journey and I hope round 2 is successful for you!! My AMH was low, around 1.5, FSH was slightly high, and follicle count was low normal. He provides weekly summaries of the latest IVF research and posts on Facebook, Instagram and TikTok regularly. A few rounds of heavy- duty antibiotics cleared it up. As someone else mentioned adding prednisone, I also had a steroid but mine was the Medrol Dose pack which is basically the same idea. Next lets look at how mosaics perform in terms of miscarriage (often using euploids as a control so for you euploid people out there, you might want to check the next section also!). Additionally, my RE says sometimes they will recommend these medications even if you test negative but have recurrent pgs transfer failures with no other explanations (you might want to search autoimmune immune protocol on these boards). What are the differences between the two tests? Your experience is so inspiring, thank you for sharing . She is pregnant right now from that cycle. However we now understand that the chromosomes are only part of the issue. Multiple losses due to chromosomal abnormality, did you do ivf? - continued the same above protocol with the only change was that once I got my first positive beta (63) they had me increase the progesterone suppository to three times a day. I an 33 and my husband is 37. LBR was associated with morphologic parameters of euploid blastocysts, especially in women <30 years old. Note: I'm also doing a pregnancy loss blood panel to investigate clotting, and am looking into autoimmune causes as well. After 10 days, they came back and said that it was low and that i should mentally prepare myself for a chemical pregnancy. My doctor really only wants me to transfer one embryo, my husband and I want to do 2. 144 abnormal (aneuploid/mosaic) embryos and their outcomes. We had 4 blasts tested in our first IVF cycle and 2 were abnormal / 1 mosaic / and then 1 "normal". Women over 35 were not shown to have increased pregnancy rates from PGT unless they made many embryos that needed evaluation. Causes of a chemical pregnancy. Your experience gives me hope so thank you for sharing , - Estradiol patches and to apply 4 of them and change them every 2 days, - progesterone 200mg suppository morning and evening. A Group Leader is a What to Expect community member who has been selected by our staff to help maintain a positive, supportive tone within a group. Reminder: I have an integrated glossary in the text (terms are underlined with a dotted black line, and when you tap on it a window will pop up with the definition). thats a great suggestion! Pregnancy rates will be higher because not everyone will have a live birth (some miscarry). (2016)found nostatistically significantdifference inongoing pregnanciesbetween Day 5 and 6 euploids (78.6% vs 67.4%), but this was reduced by Day 7 (43.8%). They did blood tests after my miscarriage and my doctor said it was important to do it when my body still thought I was pregnant. I find the live birth rates by transfer versus by retrieval data very interesting. Don't lose hope! Next Generation Sequencing (NGS) is a new technique which boasts an impressive 99.98% consistency rate for its results. Going into my second round of IVF I was doubting anything would work. The results came back just this week saying that I was "pre-receptive" and recommended one day more of progesterone before doing the transfer to get to a more "ideal" transfer state. (I had these done at a private lab since my nurse wouldn't let me come in early) My last donor embryo cycle was also a chemical pregnancy but no PGS was done. I also did Neupogen but they still wanted to test for autoimmune disorders. For this group theyll have a better idea of what to expect. Chemical pregnancy with PGS tested embryo - Infertility - Inspire Aww happy your second round worked! Well also look at the chances of getting a euploid based on age, the impact of embryo grade and the day it was frozen (Day 5, 6 or 7), and how rebiopsies or thaw and biopsies fare for success rates. After a chemical with 2 PGS normals and two miscarriages around 8 weeks (spontaneous pregnancies) and another failed transfer, I found out I had an infection in my lining that can only be detected by a biopsy.